Villa-Boas is understandably eager to keep Defoe off the injury list given his only other recognised striker, Emmanuel Adebayor, is with Togo at the Africa Cup of Nations.
The Portuguese said: 'We acknowledged that resting him for Leeds was almost compulsory so we let him out of the game and he has made an excellent recovery so he is back on.
'In muscle injuries there is always a risk of it showing up again, but the medical department feel positive about it and the player is positive and he knows his body well.
'We believe a lot in the treatment. It is a technique that we have been using since the beginning of the season. It is not common but does happen from club to club.
'The player adhered to the treatment very, very well so we can move forward.'
Defoe's injury has resulted in Spurs stepping up their attempts to sign a new striker before Thursday's deadline. Alvaro Negredo and Leandro Damiao are both targets.
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